Chronic fatigue syndrome is in your gut — not your head

first_imgShare “Our work demonstrates that the gut bacterial microbiome in chronic fatigue syndrome patients isn’t normal, perhaps leading to gastrointestinal and inflammatory symptoms in victims of the disease,” said Maureen Hanson, the Liberty Hyde Bailey Professor in the Department of Molecular Biology and Genetics at Cornell and the paper’s senior author. “Furthermore, our detection of a biological abnormality provides further evidence against the ridiculous concept that the disease is psychological in origin.”“In the future, we could see this technique as a complement to other noninvasive diagnoses, but if we have a better idea of what is going on with these gut microbes and patients, maybe clinicians could consider changing diets, using prebiotics such as dietary fibers or probiotics to help treat the disease,” said Ludovic Giloteaux, a postdoctoral researcher and first author of the study.In the study, Ithaca campus researchers collaborated with Dr. Susan Levine, an ME/CFS specialist in New York City, who recruited 48 people diagnosed with ME/CFS and 39 healthy controls to provide stool and blood samples.The researchers sequenced regions of microbial DNA from the stool samples to identify different types of bacteria. Overall, the diversity of types of bacteria was greatly reduced and there were fewer bacterial species known to be anti-inflammatory in ME/CFS patients compared with healthy people, an observation also seen in people with Crohn’s disease and ulcerative colitis.At the same time, the researchers discovered specific markers of inflammation in the blood, likely due to a leaky gut from intestinal problems that allow bacteria to enter the blood, Giloteaux said.Bacteria in the blood will trigger an immune response, which could worsen symptoms.The researchers have no evidence to distinguish whether the altered gut microbiome is a cause or a whether it is a consequence of disease, Giloteaux added.In the future, the research team will look for evidence of viruses and fungi in the gut, to see whether one of these or an association of these along with bacteria may be causing or contributing to the illness. Share on Facebook Pinterest Share on Twittercenter_img LinkedIn Physicians have been mystified by chronic fatigue syndrome, a condition where normal exertion leads to debilitating fatigue that isn’t alleviated by rest. There are no known triggers, and diagnosis requires lengthy tests administered by an expert.Now, for the first time, Cornell University researchers report they have identified biological markers of the disease in gut bacteria and inflammatory microbial agents in the blood.In a study published June 23 in the journal Microbiome, the team describes how they correctly diagnosed myalgic encephalomyeletis/chronic fatigue syndrome (ME/CFS) in 83 percent of patients through stool samples and blood work, offering a noninvasive diagnosis and a step toward understanding the cause of the disease. Emaillast_img read more

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Unpredictable simulator training can improve pilots’ responses to surprising situations in-flight

first_imgShare LinkedIn Share on Twitter New aviation psychology research provides evidence that pilots’ responses to surprises can be improved through a particular type of simulator training. The findings suggest that predictable training scenarios are insufficient to prepare pilots for unexpected situations in-flight.“Our latest study, recently published in Human Factors, shows promising effects of unpredictability and variability in simulator training. It seems that pilots trained in this manner build better mental models, which prevents confusion and improves performance in surprise situations,” explained Annemarie Landman of Delft University of Technology, the corresponding author of the study.“The topic of surprise in flight crew is relevant right now, because aviation safety organisations have recommended that pilots are trained for surprise situations, starting in 2019.” Pinterestcenter_img Email Share on Facebook “In certain recent accidents, it seems that surprise severely disrupted the crews’ performance,” Landman said. “Perhaps these accidents could have been prevented if the pilots were better trained to deal with the aspect of surprise. However, it’s not yet clear what kind of training would be effective. So to get a better grip on this issue, we created a conceptual model of startle and surprise.”Prior to their simulator study, Landman and her colleagues reviewed previous research on the topic to better conceptualize what was meant by a “surprise” in the context of aviation. The key to a surprise, they found, was to set up a situation that mismatched with a previously learned structure of events.“Surprise is like a warning signal to indicate that there is a mismatch between your understanding of a situation, and the real situation. It pushes you to investigate and improve your understanding, so you know how to respond,” Landman explained to PsyPost.“There are a couple of issues that make it difficult to solve a surprise. One problem is that you rely — in part — on your understanding of a situation in order to interpret, or ‘frame’, what is going on. Without this perspective, you may, for instance, stare at the instruments without them making any sense to you.”“Another problem is that stress typically impairs your ability to get a good perspective on the situation,” Landman continued. “So if you’re highly surprised as well as stressed out by an emergency event, you can become ‘stuck’ in your thinking and get completely confused.”“Add to this that airplanes are extremely reliable, so when an issue does happen, it is likely more surprising than it used to be. Airplanes are also highly automated, which can make it more difficult for pilots to suddenly take manual control when this is needed.”In their simulator study, Landman and her colleagues trained 20 airline pilots to perform some maneuvers in an unfamiliar aircraft. The researchers found that pilots trained in a more unpredictable manner used throttle and airspeed more effectively in a surprise situation compared to pilots trained in a more predictable manner.“The research points to several possible training approaches. On the one hand, pilot understanding of the aircraft and of emergency events can be improved through simulator practice. This experience can be useful to ‘switch’ quickly and effectively to a new understanding in a surprise situation,” Landman said.“Also, the detrimental effects of stress and the loss of perspective in an emergency situation can perhaps be countered with stress regulation techniques, or techniques to analyse the situation in a step-wise and structured manner.”The study, “Training Pilots for Unexpected Events: A Simulator Study on the Advantage of Unpredictable and Variable Scenarios“, was authored by Annemarie Landman, Peter van Oorschot, M. M. (René) van Paassen, Eric L. Groen, Adelbert W. Bronkhorst, and Max Mulder.The review article, “Dealing With Unexpected Events on the Flight Deck: A Conceptual Model of Startle and Surprise“, was authored by Annemarie Landman, Eric L. Groen, M. M. (René) van Paassen, Adelbert W. Bronkhorst, and Max Mulder.last_img read more

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COVID-19 Update Barbados

first_imgThere were no new positive cases of COVID-19 among the 28 people tested on Whit Monday. Additionally, none of the nine people remaining in isolation has recovered so no one will leave today. The number of positive COVID-19 cases recorded in Barbados remains at 92, with 76 recoveries and seven deaths. Oct 16, 2020 Six Eastern Caribbean countries deemed safe for travel – CDC CMO says Saint Lucia at critical stage of COVID-19 outbreak Oct 15, 2020 St. Lucia records more cases of COVID You may be interested in… The Best-dos Santos Public Health Laboratory has conducted 5,499 tests. Share this:PrintTwitterFacebookLinkedInLike this:Like Loading… More deaths from COVID-19 recorded in CARICOM countries,… Oct 16, 2020 Oct 15, 2020 St. Kitts And Nevis Confirms Two COVID-19 CasesNATIONAL STATEMENT ON COVID-19 By the Hon Wendy Colleen Phipps Minister of State with Responsibility for Health March 25, 2020 In my capacity as Minister of State with Responsibility for Health, it is my duty to inform you that as of 11:03 pm on Tuesday, March 24, 2020, the Federation…March 25, 2020In “CARICOM”CARICOM SG commends regional response to COVID-19CARICOM Secretary-General, Ambassador Irwin LaRocque, has commended the health emergency response mechanism engineered by the Caribbean Public Health Agency (CARPHA) to keep the Community free of the novel coronavirus (COVID-19). Secretary-General LaRocque said the inter-agency collaboration that was taking place was another example of the co-ordination required to address the…February 18, 2020In “31Intersessional”Bahamas, Suriname and Jamaica record COVID deathsThe Bahamas, Suriname and Jamaica all recorded deaths from the coronavirus (COVID-19) pandemic over the past 24 hours (Aug 26) with Barbados recording three new positive cases. The Ministry of Health in Nassau said that 15 additional confirmed cases were recorded pushing the total number of confirmed cases to 1,813.…August 27, 2020In “General”Share this on WhatsApplast_img read more

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Authors Night Books A New Location

first_img EAST HAMPTON, NY – AUGUST 12: Alec Baldwin and Hilaria Baldwin attend Authors Night 2017 At The East Hampton Library at The East Hampton Library on August 12, 2017 in East Hampton, New York. (Photo by Eugene Gologursky/Getty Images for East Hampton Library) EAST HAMPTON, NY – AUGUST 12: Robert Caro attends Authors Night 2017 At The East Hampton Library at The East Hampton Library on August 12, 2017 in East Hampton, New York. (Photo by Eugene Gologursky/Getty Images for East Hampton Library) EAST HAMPTON, NY – AUGUST 12: Malcolm Nance attends Authors Night 2017 At The East Hampton Library at The East Hampton Library on August 12, 2017 in East Hampton, New York. (Photo by Eugene Gologursky/Getty Images for East Hampton Library) EAST HAMPTON, NY – AUGUST 12: Dennis Fabiszak and Sheila Rogers attend Authors Night 2017 At The East Hampton Library at The East Hampton Library on August 12, 2017 in East Hampton, New York. (Photo by Eugene Gologursky/Getty Images for East Hampton Library) EAST HAMPTON, NY – AUGUST 12: Chris Whipple attends Authors Night 2017 At The East Hampton Library at The East Hampton Library on August 12, 2017 in East Hampton, New York. (Photo by Eugene Gologursky/Getty Images for East Hampton Library) Emily Jane Fox Author Photo credit Jamie Emmerman Share As the previous 13 “Authors Nights” have shown, book-minded and celeb-conscious summer folk will want to be anything but “far from the madding crowd” (apologies to 18th Century poet Thomas Grey and to 19th Century novelist Thomas Hardy who took his Madding Crowd title from Grey’s Elegy), when East Hampton Library presents its annual premier literary event on Saturday, August 11.And “premier” it is, for authors as well as attendees. Nelson DeMille, a regular at Authors Night, calls the library bash “the largest, most well-attended, and most elegant authors’ event” he has ever been to.The number of attendees who mill around at the book-signing cocktail reception, nibbling on delicious hors d’oeuvres and drinking wine, or who also go the private-home dinner parties afterward, is probably equal to the number of writers who hope to get invited to the star-studded media event in the first place. Only about 100 writers make it to the expansive white tent, however, where they get to sit in alphabetical order, copies of their latest works displayed alongside catchy come-ons.The alphabetical arrangement sometimes makes for strange bedfellows, but that’s part of the fun, as fiction and nonfiction genres jostle and well-known names share table space with new authors. It’s a see-and-be-seen scene. And a select one.Library director and Authors Night co-chair Dennis Fabiszak and East Hampton Library Board president and Authors Night co-chair Sheila Rogers rely on a volunteer selection committee to assist — a “great bunch of voracious readers who stay current on new titles, authors, and publishing trends,” Fabiszak noted.“We don’t have a hard list of criteria, but in general, we try to diversify our list to make sure Authors Night truly has something for everyone,” said Rogers, adding, “There’s a wait list — just like any popular party!” It’s grown more popular each year, “one of the largest library-author events of its kind in the country.”So how is Authors Night 2018 different from the others? For one, the venue has been moved to a new location: the “555” Field (on Montauk Highway) in Amagansett, east of the IGA. Also, this year’s live radio host for the on-air author interviews on WPPB 88.3 FM, the local NPR station, is none other than The Independent’s own Bridget LeRoy, subbing in for regular Bonnie Grice.Consistency counts, however; enough famous names who generate long book-signing lines, and affable authors eager to be chatted up about their work, past and present. Attendees can also count on an appearance from Authors Night founding honorary chair and great supporter of East Hampton Library, Alec Baldwin, who will be on hand with his wife, Hilaria Baldwin, both signing recent publications.Of the 100 participating authors this year, more than half are new faces, said Fabiszak. These include Pulitzer Prize winners, celebrities, debut novelists, New York Times bestselling writers — among them Lee Child, author of the popular Jack Reacher series; A.J. Finn, whose debut thriller The Woman in the Window topped the bestseller list for months; Emily Jane Fox, whose Born Trump is still causing a buzz, not to mention David Itzkoff, author of the Robin Williams biography. “And we’re looking forward to having Ndaba Mandela, Nelson Mandela’s grandson,” the director added. All will be featured at the dinner parties.There are also returning authors to look for, among them Robert A. Caro (with Vol. IV of LBJ), Tom Clavin, Elliott Erwitt, Florence Fabricant, Jules Feiffer, Wendy Goodman, Helen Harrison, A.M. Homes, Michael Isikoff, Steve Israel, Geraldo Rivera, Gretchen Rubin, Jill Santopolo, Nathan Turner, Dr. Ruth Westheimer, Chris Whipple, and many more — all listed on the website along with brief descriptions of their books on the website.Of course, there are the aforesaid dinner parties, this year topping out at 25 guests and taking place at “lovely homes throughout the East Hampton area,” Rogers said.How to choose? “Those who purchase dinner party tickets review the options and select five potential dinners, in order of preference.” Then, shortly before the event, “we notify them about which dinner they’ll be going to,” a surprise that is always part of the fun, she said.It should be noted, not incidentally, that the dinner hosts underwrite the costs for their dinner, with 100 percent of proceeds benefiting the library.Ticket prices are $100 for the Authors Reception only, and begin at $300 for the dinners (the purchase includes entry to the book-signing reception). Tickets may be purchased at www.authorsnight.org, by calling 631-324-0222, ext. 7, or by stopping at the East Hampton Library.Dinner party tickets should be purchased by Thursday, July 26. Tickets for the book-signing cocktail party are also available in advance and at the door on the day of the event. The cocktail party runs from 5 to 7:30 PM. The dinners start at 8 PM. The festivity runs all night. EAST HAMPTON, NY – AUGUST 12: Jill Santopolo attends Authors Night 2017 At The East Hampton Library at The East Hampton Library on August 12, 2017 in East Hampton, New York. (Photo by Eugene Gologursky/Getty Images for East Hampton Library) EAST HAMPTON, NY – AUGUST 08: Therapist/Author Dr. Ruth Westheimer attends Authors Night for the East Hampton Library on August 8, 2015 in East Hampton, New York. (Photo by Mark Sagliocco/Getty Images for East Hampton Library) EAST HAMPTON, NY – AUGUST 12: Alec Baldwin and Hilaria Baldwin attend Authors Night 2017 At The East Hampton Library at The East Hampton Library on August 12, 2017 in East Hampton, New York. (Photo by Eugene Gologursky/Getty Images for East Hampton Library)last_img read more

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Air Products complete expansion in US

first_imgGet instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270. Subscribelast_img

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Picarro pushes for Latin America market

first_imgSubscribe Get instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270.last_img

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No mercy for architects

first_imgTo continue enjoying Building.co.uk, sign up for free guest accessExisting subscriber? LOGIN Subscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our community Stay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to building.co.ukBreaking industry news as it happensBreaking, daily and weekly e-newsletters Subscribe now for unlimited access Get your free guest access  SIGN UP TODAYlast_img read more

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Semtech and Helium to Create North America’s Largest LoRa-Based Network

first_imgSemtech, a leading supplier of high performance analog and mixed-signal semiconductors and advanced algorithms, has announced a collaboration with Helium, the company behind one of the world’s first peer-to-peer wireless network. Through this collaboration, Semtech intends to develop one of the largest LoRa-based networks in North America.LongFi by Helium is a protocol purpose built for a peer-to-peer wireless network that needs to connect thousands of IoT devices to a single Hotspot or enable any device to connect to any compatible Hotspot. With the announcement of this agreement, the LoRaWAN protocol has been integrated into Helium’s LongFi architecture, making the Helium network fully compatible with the LoRaWAN protocol and available to the LoRa community of more than 8,000 active software developers.  The combination of the technologies and platforms will provide the LoRa developer community with new opportunities to create new IoT solutions for both businesses and consumers.The Helium Hotspot is a new hardware device that enables anyone to own and operate a wireless network for IoT. With Helium’s own open-sourced blockchain technology, individuals are incentivized to deploy Helium Hotspots, which simultaneously mine crypto currency and provide LoRaWAN network coverage for hundreds of square miles. Helium’s network, introduced in Q4 2019, is currently available in over 745 U.S. cities with major markets throughout the nation, including New York, Los Angeles, Chicago, San Francisco, Miami, and Austin.Combining Semtech’s LoRa Devices with Helium’s distributed; open-source approach to building a ubiquitous network allows any manufacturer, developer or application to utilize LoRaWAN compatible technology to connect devices across the nation. There are over 4,300 Helium Hotspots sold to date since nationwide shipping started in October 2019 and that number is growing.last_img read more

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Injured Bale out of Wales World Cup qualifiers

first_imgGareth Bale has been ruled out of Wales’s final two crucial World Cup qualifiers against Georgia and Ireland, Britain’s Press Association reported on Tuesday.Bale’s fitness has been a source of concern for the national side since he suffered a calf muscle strain against Borussia Dortmund in the Champions League last week.The 28-year-old missed Real Madrid’s league clash with Espanyol on Sunday but reported to the Wales camp the following morning.Wales are currently second in Group D, four points behind leaders Serbia and one point above Ireland.Two wins in the matches on Friday, away to Georgia, and next Monday, at home to Ireland, are likely to guarantee them at least a place in next month’s play-offs for a place in Russia.Bale’s absence could open the door for Liverpool teenager Ben Woodburn to make his first Wales start.The 17-year-old made a dramatic introduction last month when he scored the winner within five minutes of coming on as a second-half substitute against Austria.last_img read more

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Cooler Weather Ahead Following Unseasonably Warm Temperatures

first_imgThe Kenai Peninsula has seen unseasonably warm temperatures over the last week, with high temperatures well into the mid 30s and 40s and strong winds. According to Ahsenmacher, rain is expected throughout today, December 13, as the storm will shift inland overnight brining back a rain/snow mix and cooler temperatures into the weekend. Although temperatures are expected to drop by the weekend as the storm force moves inland, according to National Weather Forecasters out of Anchorage. Ahsenmacher: “We’ve got rain spreading northward along the Kenai Peninsula. This storm moves inland today, and then it should begin to cooler air filtering in behind that low.” Story as aired: FacebookTwitterEmailPrintFriendly分享Temperatures have been unseasonably warm for the Kenai Peninsula, and typically this time of the year temperatures stay out of the 40s, according to forecasters. Jason Ahsenmacher, NWS Forecaster: “Right now we are in a pattern where there is a very strong and amplified Western North American ridge- that ridge is allowing this process of the Bering Sea, and over the North Pacific to send all of this warm air and moisture towards the Gulf Coast. That’s why we’ve been seeing this much warmer stormier pattern that we’ve been in for the last 10-11 days now.”last_img read more

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